Brain Infection by Neuroinvasive but Avirulent Murine Oncornaviruses
نویسندگان
چکیده
منابع مشابه
Brain infection by neuroinvasive but avirulent murine oncornaviruses.
The chimeric murine oncornavirus FrCas(E) causes a rapidly progressive noninflammatory spongiform encephalomyelopathy after neonatal inoculation. The virus was constructed by the introduction of pol-env sequences from the wild mouse virus CasBrE into the genome of a neuroinvasive but nonneurovirulent strain of Friend murine leukemia virus (FMuLV), FB29. Although the brain infection by FrCas(E) ...
متن کاملEfficient infection of brain microvascular endothelial cells by an in vivo-selected neuroinvasive SIVmac variant.
A neuroinvasive/neuropathogenic SIV variant termed SIVmac182 was previously isolated and characterized (Watry et al, 1994). This neuroinvasive strain was derived from the uncloned strain SIVmac251 through serial animal passage of infected microglia, unlike previously reported neurovirulent strains. Importantly, the virus described here was isolated from a strain which already demonstrates limit...
متن کاملInduction of 7/~ T Cells in Murine Salmonellosis by an Avirulent but Not by a Virulent Strain of Salmonella choleraesuis
To elucidate the relationship between the virulence of intracellular bacterium and its ability to induce 3'/8 T cells in the host during infection, we examined the differences in appearance of 3'/8 T cells in mice infected with Salmonella choleraesuis virulent strain RF-1 carrying a virulence plasmid of 50 kb, and with avirulent strain 31N-1 cured of the 50-kb plasmid. The number of 3'/8 T cell...
متن کاملIn vitro induction of T-lymphocyte-mediated cytotoxicity by infectious murine type C oncornaviruses
We have developed a system to induce oncornavirus-specific secondary cytotoxic response in vitro. When Moloney strain of murine sarcoma virus-immune spleen cells were cultivated with purified infectious Moloney murine leukemia virus (M-MuLV) or with supernates of tissue culture cells containing infectious virus, a virus-specific secondary cytotoxic response directed against type-specific determ...
متن کاملMurine macrophages differentially produce proinflammatory cytokines after infection with virulent vs. avirulent Legionella pneumophila.
Virulent Legionella pneumophila replicate readily in thioglycollate-elicited peritoneal macrophages from genetically permissive A/J mice, but avirulent L. pneumophila do not. The production of cytokines by macrophages infected with L. pneumophila has been studied, but the correlation of bacterial virulence with immune responses of macrophages, such as proinflammatory cytokine production, is not...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Virology
سال: 2000
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.74.1.465-473.2000